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In contrast, an identical experimental setup demonstrated that SERF2 does not bind non-rG4-forming structures or unstructured RNAs, including HIV-1 TAR (5′-GGCAGAUCUGAGCCUGGGAGCUCUCUGCC-3′) 45 , four-repeat CCCCGG 46 sequences and a mutated telomeric four-repeat sequence UUACCG 47 that is known not to form G4 structures (Supplementary Fig

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IL-1β also inhibits insulin signal transduction, leading to impaired IS in adipose tissue [75]